What are the methods of dry granulation?
Dry granulation can be conducted under two processes; either a large tablet (slug) is produced in a heavy duty tabletting press or the powder is squeezed between two counter-rotating rollers to produce a continuous sheet or ribbon of materials (roller compactor, commonly referred to as a chilsonator which received its …
Which method of granulation is also known as slugging method?
Dry Granulation Advantages & Limitations: * Dusty procedure. This is also called double compression or slugging method, this is valuable alternative to direct compression, where the dose of drug is too high or to wet granulation when the drug is sensitive to heat, moisture or both.
Why dry granulation method is used?
Within the pharmaceutical industry, the dry granulation process is primarily used to increase material flowability and prevent particle segregation, facilitating faster and more consistent feeding into the tableting process.
Which of the following equipment is important in slugging method of granulation?
The original method of dry granulation employed a heavy duty tablet press to compact the dry powder. The compacting process in this case is known as slugging and the compacted material was therefore in the form of “slugs” – typically 25 mm in diameter and 10-15 mm thick.
What is purging air in RMG?
What is Purging Air in RMG? Generally, purging air is used to flush the industrial process equipment with clean air. Purging Air helps to keep the surfaces of RMG (Granulation Machine) clean and help in maintaining its effective performance.
Which of the following is related to slugging?
Dry granulation It is a process to produce granules without adding liquid solution as the substance may be sensitive to heat or moisture. Without the addition of heat and moisture, the granules require compacting. The process of dry granulation can be done through slugging.
What is skin slugging?
Slugging is a catchy term that means slathering your face with petroleum jelly as the last step of your evening skin-care routine. The practice leaves your face as slimy as slug mucus (hence the name).
What is the difference between wet and dry granulation?
Dry granulation uses mechanical compression (slugs) or compaction (roller compaction) to facilitate the agglomeration of dry powder particles, while the wet granulation uses granulation liquid (binder/solvent) to facilitate the agglomeration by formation of wet mass by adhesion.
What is amperage in RMG?
What Is Ampere Load In RMG? Ampere load is the current which is used by the chopper and impeller for the rotation of powder or granules. Ampere load is high at the start of the process and then gradually decreases as the load on the motor decreases.
What is best for slugging?
Slugging is best paired with hydrating ingredients that contain humectants like honey or aloe vera. “Slugging itself isn’t hydrating—it doesn’t infuse the skin with moisture. Rather, it just keeps the moisturizing products you’ve applied from seeping out,” Dr. Parcells says.
What are the different techniques of granulation?
Granules are prepared by two methods – Dry or wet granulation. Dry granulation includes dry mixing, slug-de-slug and roller compaction processes. Wet granulation includes aqueous granulation and non-aqueous granulation. Dry granulation can be achieved through roller compaction or slugging.
Which is better dry or wet granulation?
Importance. Dry Granulation: Dry granulation is required when producing tablets from highly moisture and heat sensitive compounds. Wet Granulation: Wet granulation is required to avoid the destruction of active components in the powder.
What are the benefits of slugging?
Benefits of slugging “By sealing the skin with an ointment, we can help prevent and minimize this water loss.” Locking in this moisture is what keeps your skin hydrated, which makes for a plump and more youthful appearance, explains King. Generally, slugging is a technique best suited to those with dry skin.
What are the design features of a slugging machine for dry granulation?
Some of the main design features of the slugging machine for dry granulation include: The bottom line: Both the type of material and design feature will determine the quality of the final product. Again, to ensure consistency (uniform powder slugs and densified granules) in the manufacturing process, you must take the following precautions:
Is slugging of granules no longer used?
For many years, slugging machine played a pivotal role in dry granulation process. However, it was until the invention of a roller compactor machine that these machines are now becoming obsolete. I am not saying that these slugging of granules is no longer being used.
How to use dry granulation process?
You can use dry granulation process for a range of material processing needs in industries. All you have to do is to choose an appropriate material whose properties will not be altered by the process.
What is the slugging method?
Slugging method is one of the oldest techniques in dry granulation process. In fact, as early as the 1950s, it was a popular process in most pharmaceutical companies.