What is the Entrez ID for the TP53 gene?
7157 – Gene ResultTP53 tumor protein p53 [ (human)]
Where is the TP53 gene located?
The TP53 gene is located on chromosome 17. The Tp53 protein is a negative regulator of cell proliferation and a positive regulator of apoptosis in response to DNA damaging agents. TP53 is the most common mutated gene associated with human cancer.
How does p53 turn on transcription?
P53 turns on transcription by binding to a specific place adjacent to genes it controls and then recruits an RNA polymerase to make RNA from the genes it controls. Replication of damaged DNA and DNA repair as well as growth arrest and destruction of mutated molecules.
How many base pairs long is TP53?
The TP53 gene provides the base pair sequence from which to code for the tumor protein p53, which is 393 amino acids long.
What gene does p53 regulate?
Normal Function. The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
What are the consequences of p53 gene mutation?
TP53 gene mutations change single amino acids in p53, which impair the protein’s function. Without functioning p53, cell proliferation is not regulated effectively and DNA damage can accumulate in cells. Such cells may continue to divide in an uncontrolled way, leading to tumor growth.
What cancers are associated with p53 mutations?
Cancers Associated With TP53 Gene Mutations
- Bladder cancer.
- Breast cancer (the TP53 gene is mutated in around 20% to 40% of breast cancers)
- Brain cancer (several types)
- Cholangiocarcinoma.
- Head and neck squamous cell cancer.
- Liver cancer.
- Lung cancer (the TP53 gene is mutated in most small-cell lung cancers)
What mutations are not inherited?
Once an acquired mutation is passed down, it is a hereditary mutation. Acquired mutations are not passed down if they occur in the somatic cells, meaning body cells other than sperm cells and egg cells. Some acquired mutations occur spontaneously and randomly in genes.
What is the most common mutation?
Single base substitutions are called point mutations, recall the point mutation Glu —–> Val which causes sickle-cell disease. Point mutations are the most common type of mutation and there are two types.
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