What is fluid bed granulation?
The fluid bed granulation process (also known as agglomeration) involves suspending particles in an air stream and spraying a liquid from the top of the system down onto the fluidized bed (top-down spray). Particles in the path of the spray get slightly wet and become sticky.
What is FBD principle?
The Principle of Fluidized Bed Dryer: If air is allowed to flow through a bed of solid powdered material in the upward direction with the velocity greater than the settling rate of the particles, the solid particles will be blown up and become suspended in the air stream.
What is fluid bed coating?
Fluidized bed coating or granulation is a process by which granules or coated particles are produced in a single piece of equipment by spraying a binder as solution, suspension, or melt onto a fluidized powder bed. This process is sometimes classified as the one-pot system.
What is fluid bed agglomeration process?
The fluid bed granulation process (also known as agglomeration) involves suspending particulates in an air stream and spraying a liquid from the top down onto the fluidized bed. Particles in the path of the spray get slightly wetted and become tacky.
What are the types of granulation?
Granulation process can be divided into two types: wet granulation that utilize a liquid in the process and dry granulation that requires no liquid.
Why is wet granulation used?
Wet granulation reduces the level of dust present during manufacturing process thereby reducing the incidence of cross-contamination and risk to workers. 9. Wet granulation reduces the amount of air entrapment thereby increasing powder compressibility.
How is FBD capacity calculated?
Flow rate = Velocity x Area of cross section. Total capacity required = 884 / 0.8 = 1105 m3/hr = 651 CFM.
What is the difference between FBD and FBP?
What is the Difference Between FBD and FBP? FBD is used for only drying and, FBP is used for Granulation, Drying, Agglomeration, and Coating Process.
What is the principle of fluid bed coater?
The main principle involved in the FBP is the air suspension in which the material to be coated is suspended in the coating material with the help of air stream. Fluid bed process involves three principles viz., top spray, bottom spray and tangential spray.
What is Wurster process?
The Wurster process is recognized as the technology for precision application of a film coating onto particulate materials such as powders, crystals, or granules, and other solid ingredients with diameters ranging from 30 µm to several centimeters.
What is bed agglomeration?
Bed agglomeration is the one of the major problems during the combustion of biomass, which could cause partial or complete bed de-fluidization, and as a result, unscheduled plant shutdown. From: Comprehensive Energy Systems, 2018.
What is top spray granulation?
Top spray granulation is most commonly used to improve the flow characteristics of powder. Other advantages include increasing particle size, density, and surface area as well as reducing dust emissions.
Why slugging is done?
Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The resulting slugs are subsequently broken down into granules, which are recompressed to obtain the final tablets.
Which granulation method is best?
Among these two techniques, wet granulation is the most widespread granulation technique used despite the fact that it involves multiple unit processes such as wet massing, drying and screening, which are complex, time consuming, and expensive requiring large space and multiple equipment.
How is RMG capacity calculated?
Claimed capacity is provided by vendor in liters and to calculate capacity in kgs,first calculate bulk density of powder to be mixed and then it is multiplied by capacity in liters. claimed capaciy in liters is 400 liter and bulk density is 0.8 then capacity in kgs is 400*0.8=320kg.
Why is FBD capacity in KG?
Why FBD (Fluidized Bed Dryer) capacity measured in Kg and RMG (Rapid Mixer Dryer) capacity measured in Litre? It’s a design issue. The main functionality of RMG is “holding, mixing and granulating of standard volume”. The bulk density is product specific and may not be same for all products.
How capacity of RMG is calculated?
How is FBD CFM calculated?
What is FBP in pharma?
Now a days FBP (Fluidized bed processor) is an important technology utilized in Pharmaceutical Manufacturing. Initially used as a simple yet highly effective dryer, with the addition of spray nozzle, fluidzed bed systems quickly developed into granulators.