Is Proteus mirabilis an Mdro?
Multidrug-resistant (MDR) strains of P. mirabilis generally produce extended-spectrum β-lactamases (ESBLs) or the AmpC-type cephalosporinase and rarely carbapenemases, and their prevalence in some settings is relatively high (8, 10, 12, 13, 25, 31, 39, 41).
Is antibiotic resistance a virulence factor?
Therefore, although antibiotic resistance is not in itself a virulence factor, in certain situations it is a key factor in development of infection, and it may be considered a virulence-like factor in specific ecological niches which antibiotic-resistant bacteria are able to colonize.
Which process is most likely to result in a gene providing antibiotic resistance to be found in a viral genome?
Bacteria can acquire antibiotic resistance genes from other bacteria in several ways. By undergoing a simple mating process called “conjugation,” bacteria can transfer genetic material, including genes encoding resistance to antibiotics (found on plasmids and transposons) from one bacterium to another.
Which of the following is an example of a bacterial factor that has been shown to promote the development and spread of drug resistance in bacteria?
Which of the following is an example of a bacterial factor that has been shown to promote the development and spread of drug-resistance in bacteria? Inter- and intra-species horizontal genes transfer of bacterial antibiotic resistance genes. Binds a subunit of RNA polymerase – Rifampin.
What does Proteus mirabilis cause?
Proteus mirabilis (PM) is a Gram-negative rod-shaped bacterium and widely exists in the natural environment, and it is most noted for its swarming motility and urease activity. PM is the main pathogen causing complicated urinary tract infections (UTIs), especially catheter-associated urinary tract infections.
How does Proteus mirabilis enter the body?
Proteus mirabilis can enter the bloodstream through wounds. This happens with contact between the wound and an infected surface. The bacteria induce an inflammatory response that can cause sepsis and systemic inflammatory response syndrome (SIRS).
What are examples of virulence factors?
Factors that are produced by a microorganism and evoke disease are called virulence factors. Examples are toxins, surface coats that inhibit phagocytosis, and surface receptors that bind to host cells.
Which of the following processes is most associated with bacterial resistance acquired through plasmid transfer?
Which of the following processes is most associated with bacterial resistance acquired through plasmid transfer? Through the process of conjugation, bacteria can transfer genes to other bacteria of the same generation. They also can transfer genes between bacteria of different species.
What are the most probable mechanisms by which bacteria are developing antimicrobial resistance?
Apparently most pathogenic microorganisms have the capability of developing resistance to at least some antimicrobial agents. The main mechanisms of resistance are: limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug.
Is Proteus mirabilis a complicated UTI?
Why is Proteus mirabilis important?
P. mirabilis is capable of causing symptomatic infections of the urinary tract including cystitis and pyelonephritis and is present in cases of asymptomatic bacteriuria, particularly in the elderly and patients with type 2 diabetes (2, 3).