What is intrathecal cytarabine?

What is intrathecal cytarabine?

Cytarabine is a clear liquid. An experienced cancer doctor injects it into the fluid around the spinal cord during a lumbar puncture. This treatment is also called intrathecal cytarabine.

How is cytarabine stored?

CYTARABINE injection, powder, lyophilized, for solution: Solutions reconstituted with Bacteriostatic Water for Injection USP with benzyl alcohol may be stored at controlled room temperature, 15° to 30°C (59° to 86°F), for 48 hours. Discard any solutions in which a slight haze develops.

Can cytarabine be given intrathecally?

Cytarabine Injection may be given by intravenous infusion or injection, subcutaneously, or intrathecally (preservative free preparation only).

What is the half life of cytarabine?

Following rapid intravenous injection of cytarabine labeled with tritium, the disappearance from plasma is biphasic. There is an initial distributive phase with a half-life of about 10 minutes, followed by a second elimination phase with a half-life of about 1 to 3 hours.

What is the purpose of intrathecal chemotherapy?

Intrathecal (IT) chemotherapy is used to treat cancers that have entered into the CSF. When a cancer has gotten into the CSF, it may be called CNS (central nervous system) involvement.

What is intrathecal chemotherapy?

Listen to pronunciation. (IN-truh-THEE-kul KEE-moh-THAYR-uh-pee) Treatment in which anticancer drugs are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.

Can cytarabine be refrigerated?

27 This study27 supports refrigerated cytarabine storage for up to 28 days after puncture using aseptic technique and a CSDTD. Furthermore, diluted cytarabine (>0.08 mg/mL) did not show significant degradation in plastic syringes for up to 7 days.

How is cytarabine excreted?

The primary route of elimination of cytarabine is metabolism to the inactive compound ara-U, followed by urinary excretion of ara-U.

Does cytarabine need central line?

Drugs into your bloodstream You might need a central line. This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months.

How long does cytarabine stay in your system?

Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at risk for infection, anemia and/or bleeding. Nadir: White blood cells: 7-10 days, platelets: 12-15 days.

How long does intrathecal chemotherapy last?

The process takes about 30 minutes. Afterward, you’ll stay still for at least an hour to let the drug move through the intrathecal space. If you need many doses or will get your medicines over a long period, your doctor may suggest an implant so you don’t need as many spinal taps.

How is intrathecal chemotherapy performed?

A healthcare professional will administer intrathecal chemotherapy by injecting it into the spinal canal during a lumbar puncture. They may also administer it through a plastic insert called an Ommaya reservoir, which sits under the scalp.

Why is intrathecal chemo given?

Your doctor may recommend intrathecal chemotherapy for two main reasons: to target cancer cells in the space around the brain and spinal cord. to prevent cancer from reaching the CSF from other areas of your body.

What is the difference between epidural and intrathecal?

Intrathecal administration is delivered directly into the CSF and into the superifical spinal cord; epidural administration diffuses through the dura into the CSF, and thus has a slower onset of action.

How do you infuse cytarabine?

Cytarabine, under strict medical surveillance, is administered as monotherapy or in combination with other cytostatics, 2-3 g/m2, as intravenous infusion, for 1-3 hours every 12 hours for 2-6 days. (Total of 12 doses per cycle). A total treatment dose of 36 g/m2 should not be exceeded.

How long does cytarabine stay in the body?

Can cytarabine be administered peripherally?

Cytarabine 100 mg/ml Injection is a ready to use injection and can be administered by the intravenous and subcutaneous routes. Cytarabine 100 mg/ml Injection should not be administered by the intrathecal route due to the slight hypertonicity of this formulation.

What phase of the cell cycle is most affected by cytarabine?

Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected.

Can a nurse administer intrathecal chemotherapy?

A chemotherapy trained nurse is a nurse who has been assessed to be competent both to administer intravenous chemotherapy and check both intravenous and intrathecal chemotherapy.

What is an intrathecal injection and why is it so hazardous?

An adverse effect of intrathecal therapy is drug-induced aseptic or chemical meningitis due to direct irritation of the meninges by the drug. Intrathecal drug administration means the introduction of a therapeutic substance by injection into the subarachnoid space of the spinal cord.


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