What does bioadhesive mean?
Medical Definition of bioadhesive : tending to adhere to or cause adhesion in living tissue bioadhesive gels Encapsulating the drug in a bioadhesive polymer means that the capsule stays in the GI tract longer, allowing more drug molecules to diffuse from it and be absorbed through the intestinal walls.—
What is bioadhesive property?
Bioadhesives are natural polymeric materials that act as adhesives. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue.
What is Bioadhesion and Mucoadhesion?
Bioadhesion (and mucoadhesion) is the process whereby synthetic and natural macromolecules adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug released at the site for an extended period of time.
What are the different stages of Bioadhesion?
There are two stages in the formation of the bioadhesive joint, the first is the contact stage, when two surfaces are brought together into intimate contact, the second is the consolidation stage, when the adhesive interactions occur.
What are bioadhesive tablets?
Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal candidiasis.
How does bioadhesion work?
Bioadhesion refers to the phenomenon where natural and synthetic materials adhere to biological surfaces. An understanding of the fundamental mechanisms that govern bioadhesion is of great interest for various researchers who aim to develop new biomaterials, therapies and technological applications such as biosensors.
Is an example of bioadhesive polymer?
Based on their properties, the specific bioadhesive polymers (e.g., lectins, and fimbrins) have the ability to adhere to specific chemical structures within the biological molecules while the nonspecific bioadhesive polymers (e.g., polyacrylic acid [PAA] and cyanoacrylates) have the ability to bind with both the cell …
Is bioadhesion and mucoadhesion are same?
Leung and Robinson described mucoadhesion as the interaction between a mucin surface and a synthetic or natural polymer. Mucoadhesion should not be confused with bioadhesion; in bioadhesion, the polymer is attached to the biological membrane and if the substrate is mucus membrane the term mucoadhesion is used.
What is bioadhesive drug delivery?
The term bioadhesive describes materials that bind to biological substrates, such as mucosal membranes and in bioadhesive drug delivery systems, the term bioadhesion is used to describe the bonding or adhesion between a synthetic or natural polymer and soft tissues such as epithelial cells.
What is used in bioadhesion?
Examples of polymers used as bioadhesives include chitosan, poly(vinyl alcohol), poly(vinyl pyrrolidone), agarose, as well as the cellulose and poly(acrylic acid)-type polymers . The mucous gel layer is composed mostly of water (approx. 95% by weight), with the rest being the glycoprotein class known as mucins.
Is Carbopol a bioadhesive polymer?
Different mucoadhesive formulations containing carbopol have been developed and it was found that these demonstrated excellent mucoadhesive property and release the drug in controlled manner for a longer period of time. Tan et al. (2000) developed a bioadhesive gel incorporat- ing lidocaine using carbopol and PVP.
What is buccal drug delivery system?
Buccal delivery is defined as drug administration through the mucosal membranes lining the cheeks (buccal mucosa). The main impediment to the use of many hydrophilic macromolecular drugs as potential therapeutic agents is their inadequate and erratic oral absorption.
How is a buccal tablet given?
Buccal: To give a drug buccally, insert it between the patient’s cheek and gum (as shown below). Tell him to close his mouth and hold the tablet against his cheek until it’s absorbed. One benefit of this approach is that you can remove what’s left of a tablet from the patient’s mouth if he has an adverse reaction.
How buccal is absorbed?
Sublingual administration involves placing a drug under your tongue to dissolve and absorb into your blood through the tissue there. Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood.
Is Carbopol soluble in water?
Carbopol®* is a water soluble polymer, used as an emulsifying, stabilising, suspending, thickening in many industries and is also used as gelling agent in hand sanitizer gels and other products.
Where do you put buccal tablet?
To use the buccal tablet:
- Apply the tablet in the morning, after brushing your teeth.
- With dry hands, place the rounded side of one tablet on your upper gum above the incisor tooth.
- Hold the tablet in place by placing your fingertip over the upper lip for 30 seconds.
- Allow the tablet to dissolve.
Is buccal better than sublingual?
In conclusion, buccal nitroglycerin seems to be more efficacious than sublingual nitroglycerin. The explanation is probably that the two formulations are comparable in the treatment of acute anginal attacks, while buccal nitroglycerin has a more pronounced prophylactic effect due to its longer duration of action.